Chantix blocks nicotine from triggering the release of dopamine. The brain’s reaction to dopamine makes quitting smoking tough.īoth Chantix and bupropion affect this dopamine reaction in the brain but in different ways. The extra dopamine makes you feel good and tells your brain to smoke again. How do bupropion and Chantix work?Įvery time you smoke, the nicotine in the cigarette causes a release of dopamine - a hormone involved in the brain’s reward center. Stick with us while we talk about the differences between these two smoking cessation medications and which one might be a better option for you. If you’ve already talked to your healthcare provider about quitting smoking, they might have mentioned two prescription medications to try - Chantix (varenicline) and extended-release bupropion (Wellbutrin, Zyban). And although some smoking cessation products are available over-the-counter, it might be helpful to discuss your plan to quit with your healthcare provider. People often need to try quitting several times before they are successful. Quitting smoking is one of the biggest steps you can take to improve your health, but it can be difficult to ditch the habit for good.
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